郭晓凤,副研究员,博士,1991年10月出生于湖南郴州。
Email:guoxf@csuft.edu.cn
学习经历:
2014.09-2019.06 南开大学,元素有机化学国家重点实验室,有机化学专业,硕博连读
2016.03-2016.09 美国俄亥俄州立大学综合癌症研究中心,访问学者
2010.09-2014.06 四川师范大学,化学专业,学士
工作经历:
2023.09-至今 中南林业科技大学,副研究员
2022.01-2023.09 湖南大学,博士后/副研究员
2019.08-2022.01 湖南大学,博士后/助理研究员
研究方向:
森林保护学,林业病害的绿色防控,绿色农药的创制及机制研究,天然产物资源的利用开发。
科研项目:
1. 中南林业科技大学引进人才科研启动基金项目,2023.12-2028.12,在研,主持;
2. 国家自然科学基金青年项目(32100265),2022.01-2024.12,在研,主持;
3. 湖南省自然科学基金青年项目(2021JJ40039),2021.07-2023.12,结题,主持;
4. 中国博士后科学基金面上二等资助项目(2020M672492),2020.03-2022.02,结题,主持;
5. 国家重点研发计划“重要经济农作物蛋白质组全谱解析及逆境应答关键蛋白功能研究”重点专项项目(2021YFA1300400),2021.12-2026.12,在研,参与;
6. 国家自然科学基金面上项目(32270334),低磷信号调控独脚金内酯生物合成的机制研究,2023.01-2026.12,在研,参与;
7. 国家自然科学基金面上项目(31872007),天然源稠三环螺內酯的抗植物病毒作用机制及其先导优化,2019.01-2022.12,结题,参与;
8. 科技部国家国际科技合作专项“中俄开展绿色农药创制的联合研发”,结题,参与。
以第一或通讯作者发表论文 (共同第一作者标“†”,通讯作者标“*”):
1. Xiaofeng Guo, Bin Zhao*, Zhijin Fan*, Dongyan Yang, Nailou Zhang, Qifan Wu, Bin Yu, Shuang Zhou, Tatiana A. Kalinina, and Nataliya P. Belskaya. Discovery of novel thiazole carboxamides as antifungal succinate dehydrogenase inhibitors. J. Agric. Food Chem. 2019, 67 (6): 1647–1655 (IF=5.279, 1区).
2. Xiaofeng Guo, Dongyan Yang*, Zhijin Fan*, Nailou Zhang, Bin Zhao, Chun Huang, Fangjie Wang, Rongji Ma, Meng Meng*, and Youcai Deng*, Discovery and structure-activity relationship of novel diphenylthiazole derivatives as BTK inhibitor with potent activity against B cell lymphoma cell lines. Eur. J. Med. Chem. 2019, 178, 767-781 (IF=6.514, 1区).
3. Bin Yu, Shuan Zhou, Lixin Cao, Zesheng Hao, Dongyan Yang, Xiaofeng Guo*, Nailou Zhang, Vasiliy A. Bakulev, Zhijin Fan*. Design, synthesis, and evaluation of the antifungal activity of novel pyrazole-thiazole carboxamides as succinate dehydrogenase inhibitors. J. Agric. Food Chem. 2020, 68, 7093-7102 (IF=5.279, 1区).
4. Bin Yu, Bin Zhao, Zesheng Hao, Lei Chen, Lixin Cao, Xiaofeng Guo*, Nailou Zhang, Dongyan Yang*, Liangfu Tang, Zhijin Fan*, Design, synthesis and biological evaluation of pyrazole-aromatic containing carboxamides as potent SDH inhibitors. Eur. J. Med. Chem. 2021, 113230 (IF=6.514, 1区).
5. Long Y †,Luxi Chen †, Xiaofeng Guo †, Haixia Wang, Xiaotian Ji, Jianying Zhang, Pan Pan, Lishu Wang, Zhijin Fan*, Michael A. Caligiuri*, and Jianhua Yu*. A synthetic disaccharide derivative of diphyllin, TAARD, activates human natural killer cells to secrete interferon-Gamma via toll-like receptor-mediated NF-κB and STAT3 signaling pathways. Front. Immunol. 2018, 9:1509. (†Co-First author, IF=7.561, 2区).
6. Xiaofeng Guo, Hanxiang Su, Zhijin Fan*, Xuewen Sun, Yaozheng Sun, and Zhongxiang Qin. Synthesis, crystal structure and fungicidal activities of ethyl 2-(3-(4-fluorobenzamido) phenyl)-4-((4-fluorobenzoyl)oxy)thiazole-5-carboxylate. Chin. J. Struct. Chem. 2019, 38, 923-929 (IF=0.893, 4区).